447 research outputs found
Images in Mid-Nineteenth Century American Scientific Periodicals
This project, sponsored by the American Antiquarian Society, created a database of information about illustrations in early volumes of Scientific American (1846-1854). Electronic indices of historical documents usually allow searching only for text rather than illustrations. This database, built on RDF and accessible through a web interface, provides searching for structured, textual descriptions of illustrations. The report discusses ways of extending the project as well as the historical context of Scientific American and the technology of its time
Anterior knee pain from the evolutionary perspective
Background
This paper describes the evolutionary changes in morphology and orientation of the PFJ using species present through our ancestry over 340 million years.
Methods
37 specimens from the Devonian period to modern day were scanned using a 64-slice CT scanner. 3D geometries were created following routine segmentation and anatomical measurements taken from standardised bony landmarks.
Results
Findings are described according to gait strategy and age. The adoption of an upright bi-pedal stance caused a dramatic change in the loading of the PFJ which has subsequently led to changes in the arrangement of the PFJ. From Devonian to Miocene periods, our sprawling and climbing ancestors possessed a broad knee with a shallow, centrally located trochlea. A more rounded knee was present from the Paleolithic period onwards in erect and bipedal gait types (aspect ratio 0.93 vs 1.2 in late Devonian), with the PFJ being placed lateral to the midline compared to the medial position in quadrapeds. The depth of the trochlea groove was maximal in the Miocene period of the African ground apes with associated acute sulcus angles in Gorilla (117°) becoming more flattened towards the modern human (138°).
Conclusions
The evolving bipedal gait lead to anteriorisation of the patellofemoral joint, flattening of the trochlea sulcus, in a more lateral, dislocation prone arrangement. Ancestral developments might help explain the variety of presentations of anterior knee pain and patellofemoral instability
Design Optimization of a Quad-Rotor Capable of Autonomous Flight
An autonomous quad-rotor is an aerial helicopter with four horizontal rotors designed in a square configuration capable of locating lost or jeopardized victims, gathering military intelligence, or surveillance. The project team designed a miniaturized quad-rotor able to determine its own attitude through an onboard sensor system. A computer program using formulated control equations and an onboard processing system enables the quad-rotor to fly to a pre-determined position while correcting its attitude, which results in steady level autonomous flight
Nature tourism and Irish film
This article provides a historical overview and reading of seminal Irish film from the perspective of nature tourism. Within Irish cultural studies, tourism is frequently equated with an overly romantic image of the island, which has been used to sell the country abroad. However, using notions like the tourist gaze and taking on board influential debates around space/place, one can posit a more progressive environmental vision of nature and landscape in our readings of film
Weak Coupling Phase from Decays of Charged B Mesons to and
The theory of violation based on phases in weak couplings in the
Cabibbo-Kobayashi-Maskawa (CKM) matrix requires the phase (in a standard convention) to be nonzero. A measurement of
is proposed based on charged meson decay rates to ,
, , and the charge-conjugate states. The corresponding
branching ratios are expected to be of the order of . (submitted to
Physical Review Letters)Comment: LaTeX, 8 pages, 2 figures (not included, available upon request),
TECHNION-PH-94-7, EFI-94-14, UdeM-LPN-TH-94-19
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Membrane-To-Nucleus Signaling Links Insulin-Like Growth Factor-1- and Stem Cell Factor-Activated Pathways
Stem cell factor (mouse: Kitl, human: KITLG) and insulin-like growth factor-1 (IGF1), acting via KIT and IGF1 receptor (IGF1R), respectively, are critical for the development and integrity of several tissues. Autocrine/paracrine KITLG-KIT and IGF1-IGF1R signaling are also activated in several cancers including gastrointestinal stromal tumors (GIST), the most common sarcoma. In murine gastric muscles, IGF1 promotes Kitl-dependent development of interstitial cells of Cajal (ICC), the non-neoplastic counterpart of GIST, suggesting cooperation between these pathways. Here, we report a novel mechanism linking IGF1-IGF1R and KITLG-KIT signaling in both normal and neoplastic cells. In murine gastric muscles, the microenvironment for ICC and GIST, human hepatic stellate cells (LX-2), a model for cancer niches, and GIST cells, IGF1 stimulated Kitl/KITLG protein and mRNA expression and promoter activity by activating several signaling pathways including AKT-mediated glycogen synthase kinase-3ÎČ inhibition (GSK3i). GSK3i alone also stimulated Kitl/KITLG expression without activating mitogenic pathways. Both IGF1 and GSK3i induced chromatin-level changes favoring transcriptional activation at the Kitl promoter including increased histone H3/H4 acetylation and H3 lysine (K) 4 methylation, reduced H3K9 and H3K27 methylation and reduced occupancy by the H3K27 methyltransferase EZH2. By pharmacological or RNA interference-mediated inhibition of chromatin modifiers we demonstrated that these changes have the predicted impact on KITLG expression. KITLG knock-down and immunoneutralization inhibited the proliferation of GIST cells expressing wild-type KIT, signifying oncogenic autocrine/paracrine KITLG-KIT signaling. We conclude that membrane-to-nucleus signaling involving GSK3i establishes a previously unrecognized link between the IGF1-IGF1R and KITLG-KIT pathways, which is active in both physiologic and oncogenic contexts and can be exploited for therapeutic purposes
The Computational Complexity of Generating Random Fractals
In this paper we examine a number of models that generate random fractals.
The models are studied using the tools of computational complexity theory from
the perspective of parallel computation. Diffusion limited aggregation and
several widely used algorithms for equilibrating the Ising model are shown to
be highly sequential; it is unlikely they can be simulated efficiently in
parallel. This is in contrast to Mandelbrot percolation that can be simulated
in constant parallel time. Our research helps shed light on the intrinsic
complexity of these models relative to each other and to different growth
processes that have been recently studied using complexity theory. In addition,
the results may serve as a guide to simulation physics.Comment: 28 pages, LATEX, 8 Postscript figures available from
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